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Clinical trials show Contrave produces modest weight loss (510% body weight in responders over 56 weeks), with effects primarily through central nervous system modulation rather than slowed gastric emptying or incretin hormone stimulation
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Hims & Hers started selling copycat GLP-1 injections in May of 2024, taking advantage of a loophole that allows pharmacies to compound versions of drugs that are on the FDAs official shortage list
Most reported timing is post-workout on training days, which lines up the injection with elevated blood glucose and a planned meal both of which reduce hypoglycemia risk
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The Gabor Erdosi talk about noodles with protein was interesting
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