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Non-Hormonal: Works directly on the nervous system

As a result, single-cell sequencing of liver macrophages can provide clearer insights into macrophage distribution within the liver effectively (Li et al., 2022

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In summary, the overwhelming production of ROS during MIRI, coupled with the depletion, inactivation, and dysregulation of the intrinsic antioxidant defense mechanisms and their regulatory pathways, leads to a state of severe redox imbalance