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The binding of the SARS-CoV-2 spike glycoprotein with ACE2, which triggers the virus-mediated cellular uptake, can also cause a burst of inflammatory cytokine release (a cytokine storm) partially because of the decreased availability of functional ACE2
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Current EMA guidance for synthetic peptides (EMA/CHMP/CVMP/QWP/367182/2025, effective 1 June 2026) treats manufacturing controls, characterization, specifications, and analytical control as separate parts of peptide quality assessment
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