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Furthermore, a meta-analysis of eight trials comparing semaglutide OW with SGLT2is found that semaglutide OW, at a dose of 1 mg, was significantly more effective in reducing weight and improving HbA1c than the SGLT2is evaluated (statistically meaningful at the 0.05 significance level) [20]

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Orforglipron treatment led to a significant reduction in body weight compared with controls

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J Clin Endocrinol Metab (2020) 105:e27106

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By week 36, the rate slows to roughly one pound weekly

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