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S., Rod Dunbar, P., Romero, P., Chen, J

Contraindications and Precautions Absolute Contraindications: Known hypersensitivity to ALC or formulation components Active chemotherapy with taxanes (may worsen CIPN)[10][21] Relative Contraindications/High-Risk Groups: Poorly controlled epilepsy (may lower seizure threshold)[20] Concurrent warfarin therapy (requires close INR monitoring)[18] Established cardiovascular disease (theoretical TMAO concerns)[14] Severe hepatic encephalopathy[19] Bipolar disorder (may worsen mania in some patients)[20] DETAILED REVIEWS BY CONDITION 1

However, unlike DEM which depleted GSH in a specific manner, these agents interact with sulfhydryls from proteins, leading to impairment of vital cell functions