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[8] When transit time is slowed (when stool takes more than 24 hours to be excreted), the harmful bacteria contained in the stool stay in the intestines longer, which can lead to bacterial overgrowth
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Conversely, SGLT2 inhibitors are not associated with increased HR despite natriuresis/osmotic diuresis and reduced blood pressure and plasma volume, suggestive of reduced SNS activity 6 , 81
This indicates that its proliferative and cytoprotective effects on the gut epithelium are mediated indirectly via paracrine signaling (6467)
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