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Mild burning that resolves within minutes to hours is generally considered a normal reaction, whereas persistent pain, spreading redness, or systemic symptoms warrant clinical evaluation

A crucial observation was that DSIPs activating effect on oxidative phosphorylation was selective, primarily increasing V3 without affecting VDNP, and showing no evidence of uncoupling oxidative phosphorylation

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This mechanism, while beneficial in controlled doses, can quickly become dangerous in cases of overdose, leading to a cascade of physiological responses that may require emergency intervention

Functional improvement follows pain reduction by approximately 1 to 2 weeks