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In a drug safety update, published on 28 January 2025, the MHRA cited findings of a recent European Medicines Agency (EMA) review of the available evidence for all GLP-1 and dual GIP/GLP-1 RAs, which concluded that data supports an association between the medicines and the potential risk of pulmonary aspiration during anaesthesia or deep sedation, owing to the delayed gastric emptying linked to these medicines

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The STEP program focused on semaglutide's efficacy in weight loss for individuals with and without type 2 diabetes