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Measurement of the levels of intracellular GSH and the relative expression of NRF2, GPX4 and SOD1 in tissue samples following neoadjuvant chemotherapy To further verify the role of GSH metabolism in chemotherapy resistance, we analyzed breast cancer data from the Gene Expression Omnibus (GEO) dataset (GEO: GSE140494)
GSTM3-3 and GSTM4-4
No cases of overdosage have been reported in the literature
5-Amino-1MQ may inhibit NNMT activity with possible effects on NAD+ and S-adenosylmethionine (SAM) dynamics in experimental models
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