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6,20 What is more, GST and Pgp or MRPs (eg, MRP2) are synergistic in driving the development of multidrug resistance in tumor cells 21 (Figure 2)

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A model of redox kinetics implicates the thiol proteome in cellular hydrogen peroxide responses

The reason is because your body is adjusting to the medication, and it makes you dehydrated as your appetite becomes low