You should seek urgent medical attention (call 999 or go to A&E) if you experience: Signs of a severe allergic reaction (anaphylaxis): swelling of the face, lips, tongue or throat, difficulty breathing, or a widespread rash Severe or persistent abdominal pain, especially pain radiating to the back, which may suggest pancreatitis You should contact your GP promptly if you experience: Unexplained rapid heart rate or palpitations Significant unintentional weight loss or inability to eat Symptoms of dehydration (dizziness, reduced urine output, extreme thirst) following gastrointestinal illness Any new or worsening symptoms that concern you If you suspect a side effect from any medicine including any treatment received as part of a clinical trial you can report it to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk

They also demonstrate advantages in areas such as weight loss, improved cardiovascular health, reduced risk of cardiovascular events, and potential cognitive benefits
Instead of focusing only on calorie restriction, modern research increasingly explores: Hormonal appetite regulation Gut-brain signalling Insulin sensitivity Energy expenditure Body composition Cardiometabolic risk markers This is why Retatrutide is often mentioned in the same conversation as GLP-1 receptor agonists, GIP/GLP-1 dual agonists, and other next-generation metabolic peptides
The UK regulatory picture This is the part of the story most reviews skip, and it matters
Ozempic 1 mg solution for injection in pre-filled pen SmPC (emc, product 9749)