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Research studies have used doses up to 3,000 mg/day (Salehpour 2019)

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As a selective melanocortin 1 receptor (MC1R) agonist, afamelanotide is applied in experimental settings to probe the cAMP-mediated melanogenesis cascade the intracellular signaling pathway through which MC1R governs pigmentation biology in melanocyte cell models

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Cell subclusters exhibited a varying degree of GCG expression, with the highest expression observed in the -3 and -4 subclusters (Figure 3D)

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