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Phase 2 clinical trials enrolled 338 participants across dose groups ranging from 1mg to 12mg weekly
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Stomach problems, sometimes severe, have been reported in people who use Tirzepatide
While previous fiber photometry results showed that administration of GLP-1 or liraglutide did not significantly alter ARC AgRP/NPY neuron calcium signals post 30-minute injection, after 2 hours post-injection, the rapid suppression of AgRP calcium signals after cognition of food was indeed attenuated by liraglutide [49,82,85]
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