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Our priori calculationbased on TNF- varianceensured adequate sensitivity for the primary powered biomarker, while clinical endpoints were exploratory and likely underpowered

The neuroinflammatory processes observed in obesity are similar to those seen in neurodegenerative diseases, with microglial activation, reactive astrogliosis, and insulin resistance playing key roles

Pantaleo A et al

The goal is not to restrict access to these medications