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The use of NNMT inhibitors as a potential obesity treatment has been investigated preclinically 8,9,13 , and observational clinical data suggests that increased NNMT expression and activity correlate with increased incidence of Type 2 diabetes (T2D) and risk of obesity, respectively 10,11

WeberDDAminzadeh-GohariSThapaMRedtenbacherA-SCatalanoLCapelaTet al

Another study shows that TMAO suppresses Nrf2 and its downstream antioxidant response elements, leading to increased intracellular ROS generation and reduced SOD activity (Luo et al., 2024)

PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta

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