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Most patients need testing every 3-6 months during active treatment, with baseline testing before starting medications (American Diabetes Association 2025)

The results, published in Nature Medicine in June 2024, showed liver fat reductions that surpassed every other drug studied: Source: Sanyal et al., Nature Medicine 2024 An 82% reduction in liver fat in just 24 weeks is remarkable

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[1] [3] Importantly, patients should seek urgent medical attention if they experience severe or persistent abdominal pain (especially if radiating to the back), repeated vomiting, inability to keep fluids down, signs of dehydration, or jaundice, as these may indicate serious conditions such as pancreatitis or gallbladder disease