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Side Effects and Tolerability The most common side effects are gastrointestinal: Nausea: Affects 20-40% of patients, usually most prominent during dose increases and improving over weeks

While severe hypoglycemia is uncommon with tirzepatide monotherapy due to its glucose-dependent mechanism, combining it with other glucose-lowering agents or supplements increases risk

Optimizing the use of glucagon-like peptide 1 receptor agonists in type 2 diabetes: executive summary

(2024, February 11)

In contrast, ATTR-CM, which arises from gain-of-function mutations, 260 has been the focus of all three therapeutic approaches, with multiple candidates already in clinical development (Fig