semaglutide switch to tirzepatide Switching Early Dose Escalation of Tirzepatide

Pharmacodynamics, pharmacokinetics and safety of multiple ascending doses of the novel dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 agonist RG7697 in people with type 2 diabetes mellitus

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Cardiovascular effects: Glucagon receptor agonism (via retatrutide) and GLP-1 receptor agonism have been associated with modest increases in heart rate as a class effect