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Some preclinical comparative studies have suggested that GHK-Cu performs comparably to 5% minoxidil in stimulating hair follicle growth in organ culture, though through a different mechanism minoxidil opens potassium channels and increases blood flow, while GHK-Cu acts on growth factor signaling and matrix remodeling

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As a result, the respiratory complexes shift toward a more reduced state, which augments superoxide production (Moncada and Erusalimsky, 2002

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