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This indicates that upregulation of endogenous polyamines, especially putrescine, serves as a critical mediator in BBB injury

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Validity and reliability of the novel thyroid-specific quality of life questionnaire, ThyPRO

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Furthermore, OS impairs P clearance by disrupting hepatic P metabolism (64).P is normally cleared from the circulation after it is taken up by the liver where it is metabolised by hydroxylation and conjugation into highly excretable products