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Eating protein and/or fat together with dietary fiber before carbohydrate is most effective at enhancing GLP-1 secretion
While it has been studied over one to two years in clinical trials, there is limited data beyond that time frame, especially regarding: Long-term metabolic effects Nutrient deficiencies due to reduced food intake Potential changes to gut microbiota Dependency on the drug to maintain weight loss Potential changes to gut microbiota Some clinicians have voiced concern that stopping Ozempic can result in rapid weight regain and the return of previous metabolic issues
Duration of benefits differs between methods : IV glutathione provides immediate peak plasma concentrations but benefits typically fade within 6 months of discontinuation, while oral supplementation offers sustained effects with regular daily dosing
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