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Adherence is low Despite growing demand, adherence remains a costly challenge

Government beneficiaries excluded

Liraglutide, however, has a faster adjustment period, with weekly dose increases for Saxenda and at least one week for Victoza

Important safety considerations include risk of thyroid C-cell tumors (contraindicated in MEN2 or personal/family history of medullary thyroid carcinoma), pancreatitis, gallbladder disease, hypoglycemia when used with insulin or secretagogues, and potential worsening of diabetic retinopathy in some patients

Obviously, these promising reports need to be confirmed by prospective randomized trials