Gastrointestinal effects lead: nausea, diarrhea, constipation, and vomiting, dose-dependent and clustered during escalation, mostly mild. Tirzepatide also produces a modest chronic heart-rate rise with a larger escalation-phase peak. Oral-contraceptive absorption can fall after starting and after each increase, so use backup or non-oral contraception for 4 weeks each time. What is known about concurrent metformin and tirzepatide use
Regular monitoring through blood tests can help assess your B12 levels and adjust the frequency of injections as necessary
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Moreover, certain medications, including metformin, proton pump inhibitors, and antacids may also reduce your bodys ability to absorb vitamin B12 from your diet (1, summary Vitamin B12 deficiency can manifest itself through a variety of symptoms
Too much B12 is rare, but always follow your doctors guidance