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More hippocampal neurons in adult mice living in an enriched environment
The deepest body of mechanistic work on GHK-Cu has come from Loren Pickart and collaborators, who have published extensively on its biology across more than four decades (Pickart et al., 2015) In preclinical research, GHK-Cu has been associated with effects on collagen and glycosaminoglycan synthesis in dermal fibroblast models, on hair-follicle morphology in rodent and ex-vivo skin studies, and on expression of genes involved in tissue remodeling
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Other studies have found that the level of GPX4 in brain tissue decreases significantly 24 h after cerebral hemorrhage, while increasing the level of GPX4 significantly reduces neuronal dysfunction, brain edema, blood-brain barrier damage, oxidative stress and inflammatory damage after cerebral hemorrhage, and the application of the ferroptosis inhibitor Fer-1 also significantly reduces the extent of secondary brain injury after cerebral hemorrhage 74
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