I have found this to be very effective and reducing mast cell activation
This specific biochemical modification creates a highly stable, lipophilic (fat-soluble) shield around the molecule
Kim SW, Kim S, Son M et al (2020) Melatonin controls microbiota in colitis by goblet cell differentiation and antimicrobial peptide production through Toll-like receptor 4 signalling
There are many agents with a well known depigmenting effect like pycnogenol, orchid extract, marine algae extract, cinnamic acid, soy, aloesin, Boswellia , hydroquinone, glycolic acid, arbutin, kojic acid, ascorbate, tocopherol, niacinamide, etc
As always, any unusual symptoms or concerns should be brought to the attention of a healthcare provider as soon as possible