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One of the most thoroughly investigated miRNA clusters in this regard is the miR-143/-145 family, which is enriched in VSMCs and transcriptionally regulated by serum response factor and myocardin [88, 89]

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It serves to protect cells from damage by free radicals through a process of cellular detoxification and is also protective of skin health through promoting clearer skin and reducing the appearance of aging

For tretinoin: skip the missed application and apply again the next night

Specific goals like skin brightening or detoxification require tailored frequencies