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In addition, to better describe the effect of exogenous prebiotics on overall gut microbiome stability in probiotic consumption, shotgun metagenomic sequencing successfully pointed out that continuous galactooligosaccharide supplement could promote the growth of Lactobacillus plantarum and decreased its single-nucleotide polymorphisms (SNPs) mutation under competitive conditions [106]

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A number of studies have revealed that exosomes can regulate the function of target cells by secreting their contents into the TME, using crosstalk, and/or influencing major tumor-related pathways, including EMT, CSCs, angiogenesis, and metastasis involving several cell types (Wu et al., 2017)

GLP-1 receptor is expressed in human stomach mucosa: Analysis of its cellular association and distribution within gastric glands