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The Differences Between GLP-1 and GIP Drugs Mechanism of Action GLP-1 medications primarily work by enhancing insulin secretion and reducing glucagon levels, thereby lowering blood glucose levels
Screen-based detection of intracellular cAMP Islets were plated in clear-bottom 96-well plates with KRB containing 2.8 mmol/l glucose and stimulated for 20 min at 37C with KRB (20 mmol/l glucose) plus IBMX (500 mol/l), either alone or combined with forskolin (10 mol/l), GLP-1 (1 nmol/l) or triagonist (1 nmol/l)
3-nitrotyrosine Abcam #ab116691
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