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Although the physiological role of ferroptosis remains unclear, it can be triggered by pharmacological disruption of cellular lipid peroxidation repair or by oxidative stress associated with degeneration

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Specific examples of executive functions include shifting between two behaviors, inhibiting habitual behaviors, updating information, and planning (131)

The role of R-2-HG as an oncometabolite has been implicated in epigenetic modifications through the inhibition of -KG-dependent dioxygenases and demethylases, which has been assumed to be a driver of tumorigenesis 117,118