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JAMA Internal medicine, 184 (11), 13141323
A retrospective analysis of semaglutide-treated patients with co-existing psoriasis (n=~200) demonstrated PASI 75 responses in approximately 45% rates approaching those seen with conventional systemic therapies in this obese subpopulation
It is a tightly regulated reaction that depends on both the availability of the amino acids (cysteine, glycine, and glutamate) and the rate-limiting enzyme, glutamate-cysteine ligase ( GCL )
When epicardial adipose tissue is in excess, its potential benefits on thermoregulation and mechanical protection of the heart are countered by proinflammatory activity and with a worse haemodynamic and metabolic profile in patients with HFpEF
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