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Accessed December 11, 2024 via [20] Ibid

CBS, a rate-limiting enzyme in the transsulfuration pathway, catalyzes the irreversible transformation of homocysteine and serine to cystathionine, which is the precursor of cysteine [73, 74]

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The highest risk appears to be in patients with type 2 diabetes who have established diabetic retinopathy at the time of treatment initiation, particularly when aggressive glycemic targets are pursued rapidly without appropriate ophthalmologic monitoring