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Genetic polymorphisms in NAT2 (N-acetyltransferase 2), TPMT (thiopurine methyltransferase), and glutathione S-transferase genes create phenotypic differences
Studies have shown that long-term aerobic exercise, such as running or swimming, increases the mitochondrial content in cardiomyocytes, enhances the m, and increases the activity of respiratory chain complexes, thus improving the energy supply to the myocardium (Shah et al., 2024
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However, challenges such as metabolic side effects and short half-life necessitate innovative delivery strategies, including Pegylation and gene therapy, to optimize its clinical application
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