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Suspected adverse reactions to any substance should be reported via the MHRA Yellow Card scheme at yellowcard.mhra.gov.uk
However, there were no significant effects on nonfatal myocardial infarction (RR 0.86, 95% CI 0.70 to 1.07) ( Figure 2C ), nonfatal stroke (RR 0.83, 95% CI 0.52 to 1.33) ( Supplementary Figure 2C ), unstable angina pectoris (RR 1.04, 95% CI 0.72 to 1.50) ( Figure 2D ), or HF (RR 1.01, 95% CI 0.76 to 1.35) ( Supplementary Figure 2D )
Third, the study did not recruit a sufficient number of participants to assess outcomes in those with BMI less than 25 kg m 2 or to assess outcomes of metabolic syndrome (for example, blood pressure, lipid profile, metabolic dysfunction-associated steatotic liver disease)
Engs exendin-4 discovery provided the missing piece
To choose the best treatment option, doctors need to consider the complexity of the therapy and the possible risk of side effects, such as hypoglycemia or putting on weight
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