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Sleep architecture is assessed through patient history or, where available, actigraphy or polysomnography data specifically sleep latency, REM and slow-wave sleep proportions, and sleep fragmentation index

Certain chemotherapy regimens, some antibiotics if taken for long periods, and long-term use of the epilepsy drug phenytoin, carry a risk of nerve damage

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doi:10.1016/j.neuropharm.2012.08.021 Balda MS, Whitney JA, Flores C, Gonzlez S, Cereijido M, Matter K (1996) Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intermembrane diffusion barrier by expression of a mutant tight junction membrane protein

M., Cariou, B., & Ryan, D