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However, other types of cancer occurred at a similar level between patients who took sitagliptin and those with other therapies (90)
Nrf2 is involved in not only the regulation of GSH synthesis and reduction via upgrading some enzymes and proteins (SLC7A11, GCLM, GCLC, GR) but also the activation of GSH-dependent antioxidant enzymes (GPX, GST) [200, 201]
Additionally, obesity and IR both contribute to -cell dysfunction and apoptosis, mechanistically explained by glucotoxicity and increased immunogenicity (the accelerator hypothesis) or by -cell exhaustion due to increased metabolic demand (the overload hypothesis) [23]
The most common adverse effects of tirzepatide are gastrointestinal, including nausea (occurring in 20-30% of patients), diarrhea, vomiting, constipation, and abdominal discomfort
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