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have found that GLP-1 levels are lower in the obese rat group than in the lean rat group during the first 6 h of the dark cycle and in the middle of the light cycle (56)

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Stroke Risk Similar to blood clots, theres a small increased stroke risk with oral hormone therapy, but this risk appears minimal or absent with transdermal preparations and is primarily a concern in older women (over 60) who start therapy many years after menopause

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