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Their half-lives are 13 hours (LIRA) and 7 days (SEMA), allowing for daily and weekly subcutaneous administration, respectively, thanks to the structural modifications introduced.5,10 Effects on obesity and glycaemic control Both LIRA 3 mg and SEMA 2.4 mg have demonstrated a strong appetite-suppressing and satiety-promoting effect, as well as a delaying effect on gastric emptying.11,12 The SCALE programme highlighted the efficacy of LIRA 3 mg in reducing body weight and waist circumference13 and confirmed a reduction in HbA1c levels in individuals with diabetes, along with a decreased progression from prediabetes to diabetes after three years of treatment14 (Table 1)
Rapid weight loss in people already at healthy weights can result in excessive loss of lean muscle mass, reduced bone mineral density, nutritional deficiencies, and metabolic complications
ShahSHBainJRMuehlbauerMJStevensRDCrosslinDRHaynesCet al
Kimborough CK, Griffiths CE, Finkel LJ, Hamilton TA, Bulengo SM, Ellis CN
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