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Although the mechanisms of hepatic IRI are largely unknown, several targets have been revealed to be associated with its pathogenesis by preclinical studies such as proliferators-activated receptor , family with sequence similarity 3A, and some noncoding RNAs (Yang et al., 2018)

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To explore the enhanced dependency on mitochondrial function, we further explored the acute metabolic stress imposed by 5FU treatment

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H., Jeon, Y