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2016;13(Suppl 2):S156-162

To further address the issue of whether metformin can prevent MG-induced cell apoptosis, we pre-incubated RINm5F cells in different concentrations of metformin (10, 25, 50, and 100 M) in the presence of 1 mM MG

The reaction mixture was stirred at room temperature for 6 h

Therapeutically, creatine supplementation is most effective in AGAT patients with myasthenia gravis and myopathy, and it can significantly improve or even normalize abnormal developmental scores [45]

Clinical trials have shown that the use of a lower starting dose (2 mg) compared to a higher starting dose (4 mg) can partially reduce the frequency and severity of gastrointestinal side effects