Beyond nausea, the gastrointestinal side effect cluster includes diarrhea, vomiting, constipation, and decreased appetite, which is technically a desired effect but can become problematic at extreme levels
Disis, M
Rapid weight loss from combined therapy may trigger nutrient absorption problems, especially with fat-soluble vitamins (A, D, E, K) since semaglutide slows fat digestion
Instead of only working on surface symptoms, these neuro-regulating peptides may influence how the brain responds to stress, handles anxious thoughts, and recovers from mental fatigue
Because fibroblast activity is a rate-limiting step in the closure and reorganization of experimental wounds, these cell-level observations are treated as a mechanistic starting point rather than an endpoint