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A complete blood cell count was performed on each rabbit prior to anesthesia on Day 0, and again on Days 7 and 14, to monitor for any systemic abnormalities [2]

They work through different pathways and are not interchangeable

It can also be worsened by clothing that is too tight or too thick and causes friction with the affected areas

removing vials from the carton and storing them on an open shelf under fluorescent or natural light is a documented degradation accelerant

Therefore, it is not possible to define the real activation status of the IGF-1 receptor signaling through the mere dosage of circulating IGF-1 levels