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Jeon M, Han J, Nam SJ, et al
Frequently Asked Questions How does KLOW dosage guide work
Management tip: Prioritise B-vitamin-rich foods and supplements (especially B6, B12, and folate), reduce processed foods, manage stress, and have your homocysteine levels tested regularly
You need the entire upper body elevated
The two primary MTHFR variants are C677T (rs1801133) which substitutes valine for alanine at position 222, reducing enzyme activity by approximately 35% in heterozygotes and 70% in T/T homozygotes at physiological folate concentrations and A1298C (rs1801131) which substitutes glutamate for alanine at position 429, reducing activity by approximately 20% in heterozygotes, with compound heterozygosity (C677T + A1298C) producing effects between the two individual homozygous states
