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2019 Aug;62(8):1470-1474
Given NR3C1s central role in HPA axis regulation and its known involvement in depression, such epigenetic dysregulation may represent a shared vulnerability mechanism across addiction and mood disorders
Morieri ML, Avogaro A, Fadini GP
Kmetova Sivonova, M
Your doctor should assess several factors before approving discontinuation, including your current weight status and trajectory, the presence and control of obesity-related comorbidities (type 2 diabetes, hypertension, sleep apnea, cardiovascular disease), your readiness and capacity to implement intensive lifestyle modifications, available support systems and resources, and your history of weight cycling or previous weight loss attempts
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