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Joshua Silva, MD

Evidence for the atherosclerotic benefits of GLP1RA remains consistently strong, while benefits in HF are not widely accepted

In late 2024, Zealand Pharma initiated a phase 2b randomized dose-finding obesity and T2DM + obesity clinical trial (ZUPREME-1 and ZUPREME-2) which will evaluate petrelintides efficacy and safety in individuals with obesity in a larger population ( N = 480) [116]

A 16-week study published in Metabolism: Clinical and Experimental found that participants using weekly Lipo C injections showed progressive reductions in liver fat content measured by MRI, with the greatest changes occurring between weeks 8 and 16 rather than in the first month

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