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When vitamin C donates electrons to neutralize free radicals, glutathione can restore vitamin C to its active form, and vitamin C can do the same for glutathione, creating a continuous antioxidant cycle

( E ) Mean GSH levels in A549shNRF2-BIND-luc, -BIND-WT NRF2, -BIND-Neh4/5mut cells treated with water (control) or 2.5 ng/mL dox for 48 h