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It acts as a powerful endogenous antioxidant, supporting liver detoxification, immune system regulation, and the neutralization of free radicals

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Specifically, in women who are postmenopausal, exogenous estrogen causes homocysteine levels to drop, but prior to menopause, excess estrogen may increase homocysteine.[ref][ref] Both high and low homocysteine levels increase all-cause mortality, with the caveat that the increase in mortality risk is only seen if homocysteine is not low due to vitamin intake

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weight outcomes were modest and inconsistent, and development for obesity treatment was not continued