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PMID: 23065822

The drug gave them a window, and they used it

GLP-1 agonists address this by reducing inflammatory cytokines (IL-6, TNF-, CRP) that amplify the cortisol-insulin feedback loop

Patients taking semaglutide also showed markedly lesser declines of a key metric of kidney function called the estimated glomerular filtration rate, which was particularly pronounced among those with low baseline readings indicative of impairment, the researchers said, suggesting the drug may help protect people with pre-existing kidney impairments