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Patients in the 1 mg group reduced 8.7% of body weight, those in the 4 mg group lost 17.1%, those in the 8 mg group reached 22.8%, and those in the 12 mg group achieved 24.2% compared to 2.1% in the placebo
GSH or GABA concentrations equal to 0 were interpreted as evidence of failure to fit and those data points were excluded from further analysis (SM1 n=0, Thal n=0, mPFC n=2, SMA n=2)
Opportunity Cost Analysis Compare semaglutide costs to alternatives: Gym membership: $30 to $100 monthly (many unused) Weight loss program subscriptions: $20 to $60 monthly (variable effectiveness) Prepared meal delivery: $200+ monthly (convenience but not addressing underlying appetite) At $199 monthly, compounded semaglutide costs approximately the same as many wellness expenses people already budget for, with significantly higher efficacy for weight loss
But Wensley ultimately had to switch from Zepbound to Wegovy to meet her plan's requirements
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