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ASSESSING -CELL MASS Regulation of -cell mass appears to involve a balance between the dynamic process of -cell mass expansion, through replication and neogenesis, and loss via apoptosis (Fig

Amino acid sequence: Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-OH Molecular weight: ~1025.18 Da (one water molecule heavier due to ring opening) Molecular formula: C50H71N15O10 Number of amino acids: 7 (with N-terminal acetylation, free C-terminal acid) Cyclization: None linear peptide Key difference from MT-II: Lactam bridge hydrolyzed

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The most important are the 78 kDa glucose regulatory protein (GRP78) and protein disulfide isomerase (PDI)