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Mitchell et al.[6] reported covalent binding in units of nanomoles per milligram protein, whereas in our program we calculate NAPQI covalent binding in units of molarity
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However, the intranasal route of drug delivery still has some unresolved issues, such as the need to overcome cilia and mucosal clearance in the vestibular region, as well as enzymatic degradation after the introduction of nanotherapeutic formulations into the nasal cavity[166]
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